Deciding to treat with some medications we often even don't pay attention to its side effects, not speaking about other necessary data, like pharmacological properties and pharmacokinetics. Of course, some of us may protest and say that they don't need to overload brain with excess and rather hard information, but nevertheless, this article has the right to exist. Here, we would like to speak about pharmacological properties of well known Cialis Canada or (Tadalafil).
Canadian Cialis (Tadalafil) drug is an effective, reversible, selective inhibitor of specific phosphodiesterase type 5 (PDE5) cyclic guanosine monophosphate (cGMP). When sexual stimulation causes local release of nitric oxide, inhibition of PDE5 tadalafil leads to increased levels of cGMP in the cavernous body of penis. The result is clear - relaxation of smooth muscles of arteries and blood flow to the tissues of the penis, causing erection. Tadalafil (Cialis online pills) has no effect in the absence of sexual stimulation.
In vitro studies have been shown that tadalafil is a selective inhibitor of PDE5. In Canada PDE5 is an enzyme found in smooth muscle of the corpus cavernosum, in vascular smooth muscle of internal organs, skeletal muscle, platelets, kidney, lung, and cerebellum. The action of tadalafil for PDE5 is more active than other phosphodiesterase. Tadalafil – generic Cialis from Canada is 10 000 times more potent for PDE5 than for FDE1, FDE2 and PDE4, which are located in the heart, brain, blood vessels, liver and other organs. Online cheap Cialis 10 000 times more active blocks PDE5 than FDE3 - an enzyme that is found in the heart and blood vessels. This selectivity for PDE5 compared with FDEZ is important, because FDEZ is an enzyme participating in the reduction of the heart muscle. Additionally, Cialis is approximately 700 times more potent for PDE5 than for FDE6, found in the retina. Tadalafil is also showing effect of 10 000 times more potent for PDE5 compared to its effect on FDE7 - FDE10.
Cialis improves erection and the possibility of successful sexual intercourse. The drug acts within 36 hours. The effect is manifested as little as in 16 minutes after taking the drug in the presence of sexual arousal.
In healthy individuals Cialis Canada tadalafil does not cause significant changes in systolic and diastolic blood pressure compared with placebo in the supine position (mean maximum decrease of 1, 6 / 0, 8 mm hg. art., respectively) and in the standing position (mean maximum decrease of 0, 2 / 4, 6 mm hg. art., respectively). Tadalafil does not cause significant changes in heart rate.
Moreover, Cialis from Canada does not cause changes in the recognition of colors (blue / green), due to its low affinity to FDE. In addition, there is no effect of tadalafil on visual acuity, electroretinogram, intraocular pressure and pupil size.
In the study of tadalafil in men in the daily dose of 10mg has been revealed no clinically effect of the drug on the amount and concentration of sperm motility and sperm morphology. That's gives us the reason to consider to buy Cialis online - one of the most effective and safe remedies in treatment of impotence and erectile dysfunction in Canada and United States.